Whereas estimates from mixed models that took into account heterogeneities across registries suggested that a small decrease (3% per year) in total prevalence of NTD between 1999 and 2003, this decrease followed a period of a comparable increase between 1995 and 1999. Overall, we found no clear evidence of a downward trend over the 20 year study period. In contrast, as a result of prenatal diagnosis and termination of pregnancy for fetal anomaly of most NTD in Europe, their live birth prevalence substantially decreased over time replica oakley sunglasses, especially for anencephaly.Strengths and limitations of studyThis was a large study looking at long term trends in the prevalence of NTD based on data from a number of population based registries in Europe.
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